Last edited by Grolrajas
Wednesday, July 15, 2020 | History

4 edition of Oxidative Phosphorylation in Health and Disease found in the catalog.

Oxidative Phosphorylation in Health and Disease

by Jan A.M. Smeitink

  • 389 Want to read
  • 18 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Cytology,
  • Science,
  • Medical / Nursing,
  • Science/Mathematics,
  • Anatomy,
  • Endocrinology & Metabolism,
  • Internal Medicine,
  • Medical / Endocrinology & Metabolism,
  • Relativity,
  • Energy metabolism,
  • Mitochondria,
  • Mitochondrial pathology,
  • Oxidation, Physiological,
  • Phosphorylation

  • Edition Notes

    Medical Intelligence Unit

    The Physical Object
    FormatHardcover
    Number of Pages220
    ID Numbers
    Open LibraryOL9558390M
    ISBN 100306482320
    ISBN 109780306482328

    Oxidative Phosphorylation in Health and Disease. With the new research done, this book includes updates on the normal structure, function, and molecular biology of the mitochondrial respiratory chain, information on traditional diagnostical methodologies, and an overview of the diagnostic promise of new technologies. The hypermetabolism of. 56 Oxidative Phosphorylation You have just read about two pathways in glucose catabolism—glycolysis and the citric acid cycle—that generate ATP. Most of the ATP generated during the aerobic catabolism of glucose, however, is not generated directly from these pathways.

    ADVERTISEMENTS: The upcoming discussion will update you about the difference between oxidative phosphorylation and photophosphorylation. Difference # Oxidative Phosphorylation: 1. It takes place during aerobic respiration (a catabolic process) on cristae in mitochondria. ADVERTISEMENTS: 2. It occurs during terminal oxidation of reduced coenzymes generated in glycolysis and Krebs’ cycle with. Aerobic Respiration, Part 3: Oxidative Phosphorylation You have just read about two pathways in glucose catabolism—glycolysis and the citric acid cycle—that generate ATP. Most of the ATP generated during the aerobic catabolism of glucose, however, is not generated directly from these : Lisa Bartee, Walter Shriner, Catherine Creech.

    fig Oxidative phosphorylation in mitochondrial electron transport chain (ETC), and proton leak via uncoupling proteins (UCPs). UCP dissipates mitochondrial membrane potential by facilitating proton leak across the inner membrane, thereby minimizing superoxide (O2•−) formation from undesirable interaction between molecular oxygen (O2) and high-energy electrons (e−). INTRODUCTION. Definition Oxidative stress is the presence of active oxygen species (ROS) in excess of the available antioxidant buffering capacity ().These reactive oxygen species can damage proteins, lipids and DNA, altering the organism’s structure and function (Roberts and Hubel, ). Sies and Cadenas () introduced the term from the book.


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Oxidative Phosphorylation in Health and Disease by Jan A.M. Smeitink Download PDF EPUB FB2

With the new research done, this book includes updates on the normal structure, function, and molecular biology of the mitochondrial respiratory Oxidative Phosphorylation in Health and Disease book, information on traditional diagnostical methodologies, and an overview of the diagnostic promise of new technologies.

The hypermetabolism of Luft disease, although only seen twice, is also : Hardcover. From the reviews of the first edition: "There has been a great advance in the past 60 years in the understanding of mitochondrial genetics. The current volume opens with two chapters on the basic biochemistry and molecular biology of the human OXPHOS, which are followed by seven chapters on the clinical aspects of oxidative phosphorylation disorders including animal models.

Purpose: The purpose of this book is to update readers on the current knowledge of oxidative phosphorylation in health and disease, worthy objectives. Audience: Neuroscientists and neurologists are the main audience for this book. Features: The 23 authors contribute 12 chapters to this book.

The objective of the book is to determine ways to prematurely identify, diagnose, and treat mitochondrial diseases Price: $ Oxidative Phosphorylation in Health and Disease. Mitochondrial diseases are often hard to diagnose.

From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic scientists. Oxidative Phosphorylation in Health and Disease (Medical Intelligence Unit series) by Jan A.M. Smeitink.

Mitochondrial diseases are often hard to diagnose. From the time they were first researched without animal models, patients of mitochondrial diseases.

ISBN: OCLC Number: Description: pages: illustrations ; 23 cm. Contents: The human OXPHOS system / Immo E. Scheffler --Molecular biology of the OXPHOS system / Richard C.

Scarpulla --Clinical diagnosis of oxidative phosphorylation disorders / Robert McFarland [and others] --Contribution of histopathological. Get this from a library. Oxidative Phosphorylation in Health and Disease. [Jan A M Smeitink; Rob C A Sengers; J M Frans Trijbels] -- Mitochondrial diseases are often hard to diagnose.

From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic.

Oxidative phosphorylation is a cellular process that harnesses the reduction of oxygen to generate high-energy phosphate bonds in the form of adenosine triphosphate (ATP).

It is a series of oxidation-reduction reactions that involve the transfer electrons from NADH and FADH2 to oxygen across several protein, metal, and lipid complexes in the mitochondria known as the electron transport Author: Ojas A.

Deshpande, Shamim S. Mohiuddin. Request PDF | Clinical Diagnosis of Oxidative Phosphorylation Disorders | Oxidative phosphorylation defects are a common group of inborn errors of metabo lism.

Patients may present to a variety of. Oxidative phosphorylation is the principal purpose of oxygen respiration and the principal use of breathed in oxygen to generate energy in the body. The ATP synthase revolving door resembles a molecular water wheel that harnesses the flow of hydrogen ions in order to build ATP molecules.

Oxidative phosphorylation coupled to the electron transport chain represents a highly efficient way to release energy and replenish cellular ATP.

The process requires the presence of O 2 as the final electron acceptor. It is the key part of the oxidative energy system for exercise.

Oxidative Phosphorylation in Health and Disease Autor Jan A.M. Smeitink. Mitochondrial diseases are often hard to diagnose. From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic scientists.

Recall that the production of ATP using the process of chemiosmosis in mitochondria is called oxidative phosphorylation. The overall result of these reactions is the production of ATP from the energy of the electrons removed from hydrogen atoms.

These atoms were originally part of a glucose molecule. In this chapter we describe about 18 years of experience with prenatal diagnosis in oxidative phosphorylation (OXPHOS) diseases in our centre.

Mitochondrial Oxidative Phosphorylation: Nuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology: Medicine & Health Science Books @ mat: Paperback.

Background and Purpose: Mitochondrial dysfunction remains the crucial cause for many heart diseases including diabetic cardiomyopathy (DCM).

Sirtuin-3 (SIRT-3) is a protein deacetylase localized in the mitochondria and regulates mitochondrial function. Being a noteworthy mitochondrial protein deacetylase enzyme, the role of SIRT-3 in DCM is yet to be by:   Oxidative Phosphorylation You have just read about two pathways in glucose catabolism—glycolysis and the citric acid cycle—that generate ATP.

Most of the ATP generated during the aerobic catabolism of glucose, however, is not generated directly from these pathways. Find many great new & used options and get the best deals for Medical Intelligence Unit Ser.: Oxidative Phosphorylation in Health and Disease by Rob C.

Sengers and J. Frans Trijbels (Trade Cloth) at the best online prices at eBay. Free shipping for many products. When health professionals talk about oxidative stress and free radicals, they are referring to some of the end products and results of oxidative phosphorylation.

The production of such substances, i.e., Hydrogen peroxide and superoxide, are unavoidable in the body, and can lead to an increased risk of cancer, inflammation and chronic disease.

A large number of oxidative phosphorylation defects have been described; only the most common ones are outlined here, along with their distinguishing features.

Mitochondrial mutations and variants have also been implicated in a number of diseases of aging (eg, Parkinson disease, Alzheimer disease, diabetes, deafness, cancer). Overview of mitochondrial oxidative phosphorylation. The mitochondria generate most of the energy used by cells.

Electrons from NADH + H + and FADH 2 (generated from the oxidation of acetyl-Co A in the TCA cycle) are transferred to complexes I and II of the electron transport chain (ETC). These electrons are subsequently passed along the ETC and are eventually donated to oxygen (1/2 O 2) to Cited by:   Alzheimer disease (AD) is a major cause of age-related dementia.

We do not fully understand AD aetiology and pathogenesis, but oxidative Cited by: Oxidative phosphorylation (UK / ɒ k ˈ s ɪ d. ə. t ɪ v /, US / ˈ ɑː k. s ɪ ˌ d eɪ. t ɪ v / or electron transport-linked phosphorylation) is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing the chemical energy of molecular oxygen, which is used to produce adenosine triphosphate (ATP).

In most eukaryotes, this takes place inside mitochondria.